发明名称 |
PROCESS FOR ASYMMETRIC TOTAL SYNTHESIS OF CAMPTOTHECIN |
摘要 |
The present invention provides a process for the asymmetric synthesis of camptothecin analogues as well as novel chemical intermediates of Formula I, II, and III. In general, the present process comprises conversion of a cis dioxolanone, having the same desired absolute configuration as the desired camptothecin analogue, to a compound of Formula I, II, or III, which compound is then converted to the desired camptothecin analogue. <IMAGE> (I) |
申请公布号 |
EP0705262(A4) |
申请公布日期 |
1996.02.13 |
申请号 |
EP19940919413 |
申请日期 |
1994.06.09 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
FORTUNAK, JOSEPH, M.;KITTERINGHAM, JOHN;SISTI, NICHOLAS;WOOD, JEFFERY |
分类号 |
C07D487/14;C07D471/14;C07D491/04;C07D491/052;C07D491/22 |
主分类号 |
C07D487/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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