NEW QUINOLONE CARBOXYLIC ACID INTERMEDIATES

摘要

The quinolone carboxylic acid intermediates of formula (I) or their hydrates are prepared by reacting 2 mol cpd. of formula (II) and 1 mol cpd. of formula Al(R4)3 in the inert organic solvent (pyridine, isopropyl alcohol etc.) at room temp. for 20˜30min, and pressure-reducing, concentrating and crystallizing the reactant. In the formulas, A is nitrogen or carbon; R1 is cyclopropyl, ethyl, 2-fluoroethyl or phenyl; R2 is H, methyl or amino; R3 is H, methyl, methoxy, F or cl; R4 is halogen, OH or C1-4 alkylalkoxy; X is F or cl. The intermediate cpd. (I) is useful for the prodn. of antibiotics