发明名称 |
Reshaped human antibody to human interleukin-8 |
摘要 |
A reconstituted human antibody against human interleukin-8 (IL-8), comprising (A) L chains comprising: (1) the human L-chain C region, and (2) the L-chain V region containing the human L-chain FR and the L-chain CDR of a mouse monoclonal antibody against IL-8; and (B) H chains comprising: (1) the human H-chain C region, and (2) the H-chain V region containing the human H-chain FR and and the H-chain CDR of a mouse monoclonal antibody against IL-8. As the major part of the reconstituted antibody derives from a human antibody and antigenicity of the CDR is low, this antibody has a low antigenicity against the human body, thus being expected to be applicable for medical therapy. |
申请公布号 |
ZA9505832(B) |
申请公布日期 |
1996.04.10 |
申请号 |
ZA19950005832 |
申请日期 |
1995.10.11 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
KOUJI MATSUSHIMA;YOSHIHIRO MATSUMOTO;YOSHIKO YAMADA;KOH SATO;MASAYUKI TSUCHIYA;TATSUMI YAMAZAKI |
分类号 |
C07K16/24;C12N15/13;C12P21/08 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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