发明名称 |
POLYNUCLEOTIDE COMPOSITIONS |
摘要 |
The invention provides compositions for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell. In one aspect, the invention provides a polynucleotide complex between a polynucleotide and certain polyether block copolymers. Preferably the polynucleotide complex will further include a polycationic polymer. In another aspect, the invention provides a polynucleotide complex between a polynucleotide and a block copolymer comprising a polyether block and a polycation block. In yet another aspect, the invention provides polynucleotides that have been covalently modified at their 5' or 3' end to attach a polyether polymer segment. In still another aspect, the invention provides certain preferred polycationic polymers.
|
申请公布号 |
WO9615778(A1) |
申请公布日期 |
1996.05.30 |
申请号 |
WO1995US13800 |
申请日期 |
1995.11.17 |
申请人 |
SUPRATEK PHARMA, INC.;KABANOV, ALEXANDER VICTORVICH;ALAKHOV, VALERY YULIEVICH;VINOGRADOV, SERGEY V. |
发明人 |
KABANOV, ALEXANDER VICTORVICH;ALAKHOV, VALERY YULIEVICH;VINOGRADOV, SERGEY V. |
分类号 |
C12N15/09;A61K9/107;A61K31/70;A61K31/74;A61K47/48;A61K48/00;A61P31/12;A61P35/00;C08L89/00;(IPC1-7):A61K31/00 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|