摘要 |
<p>The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val. The process is characterized in that the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys-Asp-Val is allowed to stand at room temperature with 5 to 20 unit volume of an ethanolic solution containing 0.5 to 4.0% by volume of acetic acid and 5 to 25% by volume of water, wherein the volume unit is calculated for the mass unit of the material and mass unit relates to volume unit as g relates to ml, then the crystallized peptide is separated from the crystalline suspension, preferably after cooling. Pharmaceutical compositions containing the crystalline forms of these peptides are also described.</p> |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T. |
发明人 |
NYEKI, OLGA;SCHON, ISTVAN DR.;DENES, LASZLO,DR.;HAJOS, GYOE-RGY, DR.;SZPORNY, LASZLO, DR.;IVANYI, GEZA;UBERHARDT, TAMAS;KOVACS, LAJOS;PETER, IMRE;GAZDAG, MARIA DR.;MUCK, ZSUZSANNA NEE KEREPESI;UBERHARDT, ILDIKO NEE FALUDI;LORANT, GIZELLA NEE MAREK |