| 摘要 |
PCT No. PCT/GB92/00413 Sec. 371 Date Aug. 6, 1993 Sec. 102(e) Date Aug. 6, 1993 PCT Filed Mar. 9, 1992 PCT Pub. No. WO92/15882 PCT Pub. Date Sep. 17, 1992.A method of preparing functionalized particles including (a) treating an activated substrate (CPG) with a bifunctional cross-linking agent containing a cleavable bond so as to immobilize the cross-linking agent, (b) conjugating an activated particle (P) with the immobilized cross-linking agent, and (c) cleaving the cleavable bond so as to separate the particle (P) from the substrate (CPG). The functionalized particles subsequently can be conjugated to biologically active molecules for use in assay methods.
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