A METHOD OF PREPARING A RODENTICIDE/ANTICOAGULANT COMPOUND

摘要

A method of stereoselectively preparing a beta -benzyl substituted carbonyl compound of general formula (3), in which R6 is selected from aryl and substituted aryl and R7 is a chiral auxiliary, includes reacting an alpha , beta -unsaturated carbonyl compound of general formula (2), in which R6 and R7 are as defined above with an organocuprate reagent of the general formula (1): PhCH2CuX, in which X is TMEDA. The beta -benzyl substituted carbonyl compound (3) is cyclised to give a tetralin of general formula (5), which is reduced and condensed with 4-hydroxycoumarin to produce a compound of general formula (4).