| 发明名称 |
15-Deoxyspergualin analogs, their method of preparation and their use in therapeutics |
| 摘要 |
15-Deoxy-spergualin carbamate analogues of formula NH2-C(=NH)NH(CH2)6ACH2NHCO-O-(CH2)4NH(CH2)2-*CH(R)-NH2</ SB> (I) and their addn. salts are new. A=CONH or NHCO; R=H or Me; if R is other than H, *C has (R,S) or (R) configuration. Intermediates of formulae NHR1-C(=NR1)NH(CH2)6ACH2NHCO-O-(CH2)4N(R1)(CH2) 2-*CH(R)-NHR1 (II) and HO-(CH2)4-NR1-(CH2)2-*CH(R)-NHR1 (III; R=Me) are also new. |
| 申请公布号 |
ZA9603775(B) |
申请公布日期 |
1996.11.25 |
| 申请号 |
ZA19960003775 |
申请日期 |
1996.05.13 |
| 申请人 |
FOURNIER INDUSTRIE ET SANTE |
发明人 |
LUC LEBRETON;PATRICE RENAUT;CHRISTINE DUMAS |
| 分类号 |
A61K31/27;A61K31/155;A61K31/16;A61K38/06;A61P33/02;A61P33/06;A61P37/06;C07C215/14;C07C271/20;C07C277/08;C07C279/12;C07C279/14;C07C279/24;C07K1/06;C07K5/09 |
主分类号 |
A61K31/27 |
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