| 摘要 |
The use of a modulating agent including a grouping of formula A-X-B for preparing a gamma -interferon activity modulating drug is disclosed. In said formula, each of A and B is independently an oligosaccharide group with a sufficient anionic charge such that said oligosaccharide group has an affinity for a portion of the human gamma -interferon C-terminal containing peptide sequence 125-131, and X is a spacer arm long enough to enable each of groups A and B to bind to one of said gamma -interferon homodimer C-terminal peptide sequences. Said modulating agent is particularly useful for delaying the decomposition of gamma -interferon, promoting the activation thereof and enabling it to have systemic and not just local activity. Said agent is also useful for modifying or inhibiting the local action of endogenous gamma -interferon.
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