VAGINAL RING COMPRISING DHEA OR DHEA SULPHATE AND OPTIONALLY A RELEASE-MODULATING AGENT OF THE ACTIVE PRINCIPLE, USEFUL TO INCREASE THE OVARIAN RESERVE IN WOMEN AND TO RELIEVE SYMPTOMS ASSOCIATED WITH MENOPAUSE

摘要

Sustained-release vaginal ring for comprising dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) or pharmaceutically acceptable thereof as active principle, and optionally a release-modulating agent of the active principle, wherein the amount of active principle is between 1% to 32% by weight, relative to the total weight of the formulation, and the modulator is selected from: polyvinylpyrrolidone K-30, lactose, microcrystalline cellulose and sodium lauryl sulfate. The vaginal ring of the present invention can be used to increase ovarian reserve in women, to be used as drug in assisted reproduction programs, and to relieve symptoms associated with menopause, such as symptoms of vulvar and vaginal atrophy and sexual dysfunction in postmenopausal women.