Methodologies linking patterns from multi-modality datasets

摘要

A method is disclosed to acquire imaging and non-imaging datasets from like objects. A linkage is found using a partial least squares (PLS) technique between imaging and non-imaging datasets. The linkage is then reduced to an expression of a single numerical assessment. The single numerical assessment is then used as an objective, quantified assessment of the differences and similarities between the objects. The data each dataset can be aspects of performance, physical characteristics, or measurements of appearance.

主权项

1. A computer-implemented method for assessing multi-modality datasets in the evaluation of a treatment for Alzheimer's disease, the method comprising:
receiving at a first computing device a plurality of longitudinal datasets (Di, i=1-I) regarding each of a plurality of human subjects (On, n=1-N), wherein Di is a dataset of an imaging modality captured by an imaging system and received from the imaging system over a communications network, and Dj is a dataset of a non-imaging modality received from a second computing device over the network, the Di and Djdatasets being independent datasets and forming respective square matrices; and executing instructions stored in memory of the first computing device, wherein execution of the instructions by a processor of the first computing device:
partitions each of the Di and Dj datasets into a plurality of submatrices,computes a linkage between Di and Dj using an agnostic partial least squares analysis, wherein computing the linkage includes reading the Di and Dj submatrices into memory one by one and processing the read submatrices one by one as needed to iteratively compute a single numerical assessment, wherein the single numerical assessment represents a differential effect of a treatment for Alzheimer's disease between at least two subsets of the plurality of human subjects, andreports the single numerical assessment to a user of the first computing device at a display interface of the first computing device.