COMPOSITIONS AND METHODS FOR PROMOTING BLOOD COMPONENT SURVIVAL

摘要

Compositions and methods for promoting blood component survival are described. Typically, the compositions include a population of blood components, e.g., RBCs, and an antioxidant, e.g., a lazaroid. The methods of the invention include the steps of contacting, in vitro, a population of oxidatively stressed blood components with an antioxidant in an amount and over a period of time effective to protect against oxidative stress-induced blood component damage or in an amount and over a period of time effective to increase the viability of the blood components, e.g., for a period of time greater than 28 days. Methods for inhibiting oxidative stress-induced leukocyte-mediated damage to a population of blood components are also described. These methods include contacting a population of blood components which includes leukocytes and at least one additional type of blood component with an antioxidant in an amount and over a period of time effective to protect against oxidative stress-induced leukocyte-mediated blood component damage.