| 发明名称 | Anti-DLL3 antibody drug conjugates | ||
| 摘要 | Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided. | ||
| 申请公布号 | US9480757(B2) | 申请公布日期 | 2016.11.01 |
| 申请号 | US201615135542 | 申请日期 | 2016.04.21 |
| 申请人 | ABBVIE STEMCENTRX LLC | 发明人 | Stull Robert A.;Saunders Laura;Dylla Scott J.;Foord Orit;Liu David;Torgov Michael;Shao Hui |
| 分类号 | A61K39/395;C07K16/18;C12P21/08;A61K47/48;C07K16/30;C07K16/28;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Womble Carlyle Sandridge & Rice, LLP | 代理人 | Womble Carlyle Sandridge & Rice, LLP |
| 主权项 | 1. An antibody drug conjugate of the formula M-[L-D]n, or a pharmaceutically acceptable salt thereof, wherein: M comprises an anti-DLL3 antibody that specifically binds to an epitope within the DSL domain of a DLL3 protein set forth as SEQ ID NO: 3 or 4, wherein M is an internalizing antibody; L comprises a linker; D comprises a cytotoxic agent; and n is an integer from 1 to 20. | ||
| 地址 | North Chicago IL US | ||