Methods and compositions for treatment of halitosis

摘要

Methods and compositions for treatment of halitosis are provided; devices and methods, such as a palatal patch, including a tablet or strip having a bioadhesive component and active ingredients are further provided; the bioadhesive component allows for the palatal patch to be attached to the upper palate and for the active component to be released into the oral cavity and/or GI tract; compositions for the active ingredient include composition for treatment of halitosis, anti-acids, vitamins, anti-smoking agents, etc; an herbal composition for treatment of halitosis including Echinacea, Lavender, Mastic Gum and Sage and a method of manufacturing a medicine from the herbal composition are provided as well; a device for delivery of the palatal patch to the upper palate including a housing and piston is also provided.

主权项

1. A method of manufacturing a medicine for treatment of halitosis, said medicine being applicable to saliva secreted into oral cavity, said method comprises:
(a) determining a target salivation rate at which said saliva secreted into said oral cavity; (b) selecting a desired effective duration time for a single serving dosage of said medicine, wherein during said desired effective duration of time a concentration of said medicine in said saliva within said oral cavity is sufficient to effectively prevent halitosis; (c) calculating or defining a diffusion coefficient of an appropriate pharmaceutical excipient configured to dissolve at a predefined dissolution rate within said saliva; (d) respectively defining or calculating a total mass of said pharmaceutical excipient to be used for said single serving dosage of said medicine; (e) calculating a total mass of an active ingredient to be used for said single serving dosage of said medicine in combination with said pharmaceutical excipient, wherein said active ingredient comprises a herbal composition comprising:
(1) an effective amount of Echinacea configured to sustain a concentration which does not exceed one percent of weight of said Echinacea per volume of said saliva, at least during said desired effective duration of time;(2) an effective amount of Lavender configured to sustain a concentration which does not exceed one percent of weight of said Lavender per volume of said saliva, at least during said desired effective duration of time;(3) an effective amount of Mastic Gum configured to sustain a concentration which does not exceed one percent of weight of said Mastic Gum per volume of said saliva, at least during said desired effective duration of time, and(4) an effective amount of Sage configured to sustain a concentration which does not exceed one percent of weight of said Sage per volume of said saliva, at least during said desired effective duration of time; (f) formulating said pharmaceutical excipient and said active ingredient into said single serving dosage of said medicine.