Synergistic microbicidal combinations

摘要

Antimicrobial compositions based on the synergistic combination of 2-methyl-3-isothiazolone and selected commercial microbicides where the compositions are substantially free of halogenated 3-isothiazolone, are disclosed. Particularly preferred are combinations of 2-methyl-3-isothiazolone together with benzoic acid, citric acid, sorbic acid, 1,2-dibromo-2,4-dicyanobutane, 1,3-dimethylol-5,5-dimethylhydantoin, phenoxyethanol, benzyl alcohol, zinc pyrithione or climbazole, that provide enhanced microbicidal efficacy at a combined active ingredient level lower than that of the combined individual 3-isothiazolone and commercial microbicide effective use levels.

主权项

1. A microbicidal composition consisting of 2-methyl-3-isothiazolone and zinc pyrithione which is effective for inhibiting growth of a microorganism selected from a mold, a yeast or a bacteria, wherein either (a) the ratio of 2-methyl-3-isothiazolone to zinc pyrithione is from 1/0.03 to 1/0.67, and over such range the composition exhibits synergy for inhibiting growth of Aspergillus niger; (b) the ratio of 2-methyl-3-isothiazolone to zinc pyrithione is from 1/0.0013 to 1/0.67, and over such range the composition exhibits synergy for inhibiting growth of Candida albicans; or (c) the ratio of 2-methyl-3-isothiazolone to zinc pyrithione is from 1/0.2 to 1/2.7 and over such range the composition exhibits synergy for inhibiting growth of Pseudomonas aeruginosa.