A method of DNA fragmentation is provided. The method comprising incubating a semi-solid biological sample which comprises the DNA with an auxiliary domain- directed nuclease having a binding affinity and selectivity to pre-defined sites in the DNA so as to yield a DNA fragment-of-interest, to thereby fragment the DNA.
申请公布号
WO2016178207(A1)
申请公布日期
2016.11.10
申请号
WO2016IL50394
申请日期
2016.04.14
申请人
RAMOT AT TEL-AVIV UNIVERSITY LTD.;TSINGHUA UNIVERSITY;INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES (IMCAS)
