发明名称 |
Cytoplasmic modulators of integrin regulation/signaling |
摘要 |
The present invention provides purified and isolated polynucleotides encoding IRP (Integrin Regulatory Protein) polypeptides which regulate beta2 and beta7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes. |
申请公布号 |
AU2802497(A) |
申请公布日期 |
1997.11.07 |
申请号 |
AU19970028024 |
申请日期 |
1997.04.15 |
申请人 |
ICOS CORPORATION |
发明人 |
DONALD E. STAUNTON;BRIAN P. LIPSKY |
分类号 |
G01N33/566;C07K14/47;C07K16/18;C07K16/40;C12N5/10;C12N5/16;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/91 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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