IMMUNOMODULATING COMPOUNDS COMPRISING D-ISOMERS OF AMINO ACIDS

摘要

Compounds having immunomodulatory activity which are peptide-type compounds, or variants of fragments thereof, including the N-terminal acylated and C-terminal amidated or esterified forms of up to 30 amino acids wherein the peptide-type compound comprises the formula (a): R aa<76-77> L aa<79-84> or (b): aa<84-79> L aa<77-76> R, wherein aa<76> is E or V; aa<77> is D, S or N; aa<79> is R or G; aa<80> is I or N; aa<81> is a small or hydrophobic amino acid; aa<82> is R or L; aa<83> is G or R; aa<84> is a small or hydrophobic amino acid; wherein, in said compound, at least one of the amino acids is the D isomer. These compounds are used by themselves or in combination with immunosuppressant drugs, to reduce CTL activation, particularly in association with transplantation.