NOVEL COUMARIN QUINOLONE CARBOXYLIC ACIDS AND PROCESSES FOR THE PREPARATION THEREOF

摘要

The present invention relates to novel coumarin quinolone carboxylic acids wherein the pyridone system is fused in 3,4-, 6,7- and 7,8-positions of the coumarin system, of the general formula I (see fig. I) wherein R1R2 = -NHCH=C(CO2R6)CO-, R3=NO2 or NH2, R4=R5=H, R6 = H or C2H5; R1R2 = -NHCH=C(CO2R6)CO-, R3 = R4 = H, R5 = F, R6 = H or C2H5; R1R2 = -CO(CO2R6)C=CHNH-, R3 = R4 = R5 = H, R6 = H or C2H5; R1R2 = R3R4 = -NHCH=C(CO2R6)CO-, R5 = H, R6 = H or C2H5; R1 = H or OH, R2 = R5 = H, R3R4 = -NHCH=C(CO2R6)CO-, R6 = H or C2H5; R1 = OH, R2 = R3 = H, R4R5 = -CO(CO2R6)C=CHNH-, R6 = H or C2H5; R1 = R5 = H, R2 = CH3 or CF3, R3R4 = -CO(CO2R6)C=CHNH-, R6 = H or C2H5, as well as pharmaceutically acceptable salts thereof. The object of the invention are also processes for the preparation of novel coumarin quinolone carboxylic acids and the biological action thereof.