发明名称 |
Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
摘要 |
Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention. The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain. The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.
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申请公布号 |
US5726169(A) |
申请公布日期 |
1998.03.10 |
申请号 |
US19930097384 |
申请日期 |
1993.07.26 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
SCHERZ, AVIGDOR;SALOMON, YORAM;FIEDOR, LESZEK |
分类号 |
A61K31/555;A61K38/00;A61K38/22;A61K39/395;A61K41/00;A61K47/48;A61K49/00;A61N5/06;A61P35/00;A61P43/00;C07D487/22;C07K1/113;C07K5/023;C07K14/575;C07K14/685;C07K14/795;C07K16/00;C12N9/18;C12P17/18;G01N33/50;G01N33/574;(IPC1-7):A61K31/40 |
主分类号 |
A61K31/555 |
代理机构 |
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主权项 |
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地址 |
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