NEW PHARMACEUTICAL PARENTERAL FORMULATION OF A THROMBIN INHIBITOR

摘要

A pharmaceutical formulation of a thrombin inhibitor for parenteral use having an extended release effect, as well as a process for its preparation and the use of the formulation in arterial and/or venous thromboembolism, the extended release formulation comprising a thrombin inhibitor selected from the group consisting of melagatran, inogatran and their physicologically acceptable water soluble salts, and one or more block copolymer having the general formula: HO[C2H4O]a[C3H6O]b[C2H4O]aH, wherein each a independently is an integer 1 - 250 and b is an integer 1 - 250 and wherein the formulation has a solution-gelation transition temperature below 37 DEG C.