发明名称 |
ANTIBODY FOR SKEWING SEX RATIO AND METHODS OF USE THEREOF |
摘要 |
A purified antibody, or an antigen-binding fragment thereof, is provided that binds selectively to a protein specific to an X-chromosome of a mammalian sperm cell. The sperm cell protein comprises an amino acid sequence set forth in SEQ ID NOs: 4 and 9-16. The antibody or antigen-binding fragment thereof may be derived by immunization of a host by an antigenic peptide composition comprising one or more natural or synthetic antigenic peptide sequences set forth as SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NOs: 4 and 9-16. The antibody finds utility in identifying an X-chromosome bearing sperm cell population, and in methods for skewing a sex ratio in mammals. |
申请公布号 |
EP3107554(A1) |
申请公布日期 |
2016.12.28 |
申请号 |
EP20150752006 |
申请日期 |
2015.02.19 |
申请人 |
University of Tennessee Research Foundation |
发明人 |
EDWARDS, J., Lannett;RISPOLI, Louisa, A.;SCHRICK, F., Neal |
分类号 |
A61K35/52 |
主分类号 |
A61K35/52 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|