发明名称 |
Stabilized interface for iontophoresis |
摘要 |
An interface is formed by incorporating (1) a mixture comprising a water-soluble protein and a drug into a matrix, or preferably (2) a mixture comprising a water-soluble protein and a drug to a porous matrix coated with a cationic surfactant or other ionic surfactant. The coating amount of the ionic surfactant is about 0.1 to 50 mu g, and the content of the water-soluble protein is about 0.1 to 1,500 mu g, each per 1 cm2 of the matrix. The water-soluble protein includes an albumin and the drug includes a physiologically active peptide or protein, for example. The use of the stabilized interface inhibits decrease of the drug retaining amount, and insures an effective transdermal drug delivery with a high repeatability and accuracy.
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申请公布号 |
US5837281(A) |
申请公布日期 |
1998.11.17 |
申请号 |
US19960614375 |
申请日期 |
1996.03.12 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD.;ADVANCE CO., LTD.;TEIKOKU HORMONE MFG. CO., LTD. |
发明人 |
IGA, KATSUMI;MISAKI, MASAFUMI;OKABE, KEIICHIRO;KYO, EMI |
分类号 |
A61N1/30;(IPC1-7):A61K9/70;A61M37/00;B32B3/00 |
主分类号 |
A61N1/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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