P-SELECTIN TRANSLOCATION TO VASCULAR EPITHELIAL LUMEN BY IONIZING RADIATION

摘要

The present invention relates to the use of P-selectin as a targeting agent in radiotherapies for vascular related disease. P-selectin is translocated to the lume of vascular endothelia as a result of radiation. Thus, P-selecting provides a target for receptor-mediated delivery of drugs, including anticancer drugs and drugs for the treatment of vascular disease. However, P-selectin also plays a role in the activation of certain inflammatory cells and, as such, plays a role in radiation-induced inflammation. By interfering with P-selectin induction of inflammation, it is possible to modulate inflammatory responses to radiation therapy.