发明名称 |
Soluble molecule related to but distinct from ICAM-1 |
摘要 |
The present invention relates to a soluble form of intercellular adhesion molecule (sICAM-1) and purified and isolated human sICAM-1. This invention also relates to a purified and isolated DNA sequence encoding sICAM-1. The extracellular domain of sICAM-1 and insoluble ICAM-1 are substantially the same. ICAM-1 is involved in the process through which lymphocytes attach to cellular substrates during inflammation and serves as the major human rhinovirus receptor (HRR). sICAM-1 therefore has both the property of reducing immune inflammation and inhibiting infection of rhinovirus and Coxsackie A virus.
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申请公布号 |
US5849699(A) |
申请公布日期 |
1998.12.15 |
申请号 |
US19950425989 |
申请日期 |
1995.04.20 |
申请人 |
BAYER CORPORATION |
发明人 |
MCCLELLAND, ALAN;GREVE, JEFFREY M. |
分类号 |
A61K38/00;C07K14/705;C07K16/28;C12N5/10;C12N15/41;C12P21/08;(IPC1-7):A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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