发明名称 COMPOSES BI-AROMATIQUES RELIES PAR UN RADICAL PROPYNYLENE OU ALLENYLENE ET COMPOSITIONS PHARMACEUTIQUES ET COSMETIQUES LES CONTENANT
摘要 The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), (b) or (c); Z being O or S, R1 is -CH3, -CH2-O-R6, -OR6 or -COR7; R2 is -OR8, -SR8 or a polyether radical if in the latter case R4 is C1-C20 alkyl and is in ortho or meta position relative to X-Ar; R3 is alkyl or R2 and R3 together form a cycle optionally interrupted by O or S; R4 is H, halogen, C1-C20 alkyl, -OR8, a polyether or aryl radical; R5 is H, halogen, C1-C20 alkyl or -OR8; R6 is H, alkyl or -COR9; R7 is H, alkyl, -N(r')(r") or -OR10; R8 is H, alkyl or -COR9; R9 is alkyl; R10 is H, C1-C20 alkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r' and r'' are H, alkyl, mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which R11 is H or -OR6; R12 is H or alkyl; or R11 and R12 form an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I).
申请公布号 FR2764604(A1) 申请公布日期 1998.12.18
申请号 FR19970007358 申请日期 1997.06.13
申请人 CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) 发明人 BERNARDON JEAN MICHEL;TROUILLE SIMON
分类号 A61K8/00;A61K8/14;A61K8/30;A61K8/31;A61K8/33;A61K8/35;A61K8/36;A61K8/368;A61K8/37;A61K8/39;A61K8/44;A61K8/46;A61K8/49;A61K8/60;A61K8/64;A61K31/192;A61K31/22;A61K31/35;A61K31/352;A61K31/382;A61P9/00;A61P9/10;A61P11/00;A61P17/00;A61P17/02;A61P17/06;A61P17/10;A61P17/14;A61P17/16;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P37/08;A61Q5/00;A61Q5/02;A61Q19/00;A61Q19/02;A61Q19/10;C07C65/19;C07C65/28;C07C69/76;C07D213/79;C07D311/58;C07D335/06;C07D405/06;C07D409/06;(IPC1-7):C07D311/74;A61K31/38;A61K7/48;A61K7/06;A61K7/40 主分类号 A61K8/00
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