发明名称 |
METHOD OF LAPPACONITINE HYDROBROMIDE PREPARING |
摘要 |
FIELD: chemical-pharmaceutical industry. SUBSTANCE: invention relates to preparing lappaconitine hydrobromide (allapinine) that is used as medicinal antiarrhythmic agent. Method involves extraction of monkshood (Aconitum septentrionale) roots and herb or monkshood (Aconitum leucostomum) roots and herb with 50-80% (by volume) an aqueous acetone. Impurities are removed from evaporated and acidified extract by single treatment with dichloroethane and alkaloids from an alkaline solution are isolated by 2-3-fold extraction with dichloroethane or ethyl acetate. EFFECT: simplified technology, high yield and purity of the end product. 1 tbl, 12 exv
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申请公布号 |
RU2123347(C1) |
申请公布日期 |
1998.12.20 |
申请号 |
RU19960105244 |
申请日期 |
1996.03.19 |
申请人 |
INSTITUT ORGANICHESKOJ KHIMII UFIMSKOGO NAUCHNOGO;TSENTRA RAN |
发明人 |
JUNUSOV M.S.;TSYRLINA E.M.;JUNUSOVA S.G.;DOKICHEV V.A.;SAVENKO A.N.;ISTOMIN N.N.;LISHTAKOV A.I.;GALJAUTDINOV A.A. |
分类号 |
A61K36/714;A61K125/00;A61K135/00;A61P9/06;(IPC1-7):A61K35/78 |
主分类号 |
A61K36/714 |
代理机构 |
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地址 |
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