METHOD OF PRODUCING A 19P2 LIGAND

摘要

Disclosed is a method for the production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia. The method involves cleavage of a peptide bond on an amino terminal side of a cysteine residue in a fusion protein or peptide having a 19P2 ligand fused to a protein or peptide having the cysteine residue at the N-terminus. The cleavage may be carried out, for example, by cyanylation followed by ammonolysis or hydrolysis.