METHODS OF DIAGNOSING MUSCLE DAMAGE

摘要

A method for assessing muscle damage in a biological sample obtained from a subj ect is disclosed. The method involves obtaining a biological sample from a subject bein g assessed for muscle damage, and evaluating the sample for the presence or absence of a myofil ament protein modification product. The method can also be used to assess the extent and/or ty pe of muscle damage in a subject by studying the profile of myofilament protein modification products detected in the sample taken from the subject. The invention further provides a method for screening for an agent which modulates the level of a myofilament protein modifi cation product present in a biological sample or for a calcium sensitizing agent. The invention is applicable to cardiac muscle and skeletal muscle.