4-AMINOPYRIDINES AND A PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new 4-aminopyridines of the general formula (I): where R means groups R6-SO2-NR7-, R6-NR7-SO2-, R6-SO2-O-, R6-O-SO2-; R means hydrogen or halogen atom, cyano-, alkyl-, alkoxyl- or halogenalkyl-group; X means oxygen or sulfur atom or NH-group; R and R are similar or distinct and mean hydrogen atoms or alkyl-groups; R means hydrogen atom, alkyl- or aralkyl-group; R means alkyl-, cycloalkyl-, aryl-, heteroaryl-, aralkyl- or heteroarylalkyl-group; aryl- or heteroaryl-groups can be substituted mono- or multiplied with nitro-group, halogen, hydroxyl, amino-group, carboxyl, halogenalkyl, alkoxycarbonyl, aralkoxycarbonyl, alkyl, cycloalkyl, alkoxyl, alkylamino-group or one or some groups -Y--CO2R , -O-Y--CO2R ; alkyl groups can be mono- or multiplied substituted with halogen; R means hydrogen, alkyl, cycloalkyl or alkenyl residues and these residues can be mono- or multiplied substituted with halogen, hydroxyl, alkoxyl, amino-group or alkylcarbonyl, or means cyanoalkyl, heteroaryl, aryl or aralkyl residues; aryl or heteroaryl residues can be mono- or multiplies substituted with carboxy-group, or means residue -Y--CO2R or -Y--CONR8R ; Y means linear or branched alkylene chain; R and R are similar or distinct and mean hydrogen or alkyl-groups that can be mono- or multiplied substituted with hydroxyl, alkoxyl, amino-group or carboxyl, or R and R together with N-atom with which they are bound form saturated ring that can has additionally oxygen, sulfur or nitrogen atom, and their physiologically acceptable salts also. 4-Aminopyridine of the formula (I) according p. 1 where R means groups R6-SO2-O-, R6-O-SO2-; R6-NR7-SO2-; R means hydrogen or halogen atom, alkyl, alkoxyl or trifluoromethyl-group; X means oxygen atom or NH-grou