| 发明名称 |
CANCER TREATMENTS USING COMBINATIONS OF MEK TYPE 1 AND ERK INHIBITORS |
| 摘要 |
The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in need thereof. The method comprises administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD-523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a type 1 MEK inhibitor or a pharmaceutically acceptable salt thereof, to treat or ameliorate the effects of the cancer. Additional methods for effecting cancer cell death are also provided. |
| 申请公布号 |
US2016310477(A1) |
申请公布日期 |
2016.10.27 |
| 申请号 |
US201415105945 |
申请日期 |
2014.12.19 |
| 申请人 |
BIOMED VALLEY DISCOVERIES, INC. |
发明人 |
Saha Saurabh;DeCrescenzo Gary;Roix Jeffrey James |
| 分类号 |
A61K31/4439;A61K31/365;A61K31/5377;A61K45/06 |
主分类号 |
A61K31/4439 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating or ameliorating the effects of a cancer in a subject in need thereof comprising administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD-523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a type 1 MEK inhibitor or a pharmaceutically acceptable salt thereof, to treat or ameliorate the effects of the cancer. |
| 地址 |
Kansas City MO US |
