| 摘要 |
Solid-phase-bound processes are disclosed for the systematic preparation of chemical compounds from the group of the phosphinic or phosphonous acids or their derivatives, and corresponding substance libraries which can be used for test purposes, in particular tests for biological effects. Compounds having the formula (I) YR<1>P(=O)(OR<3>)R<2>, in which Y, R<1>, R<2>, R<3> are defined as in Claim 1, are prepared by reacting a resin linker addition product (II) [resin polymer]-[linker-Z-E<1>-S<1>]n with a phosphinate (III) A<1>-O-(PHO)A*, in the presence of a suitable Pd catalyst, causing the substitution of group S<1> and yielding compound (IV) [resin polymer]-[linker-Z-E<1>-P(H)(=O)-OA<1>"], and after resin-bound derivatisation reactions, by separating the compound (I) from the resin-linker addition product. Also disclosed are the intermediate steps and resin-bound intermediate compounds, as well as the resultant substance libraries. |
