The expression of proteins is improved by post-translational transport to a cellular membrane, especially transport to the extracellular space, by the use of membrane-targeting sequences. One specific use of this method is in the expression of the DNA coding sequence for the sweet-protein brazzein: transport to the extracellular space greatly increases the expression levels.
申请公布号
WO9925835(A1)
申请公布日期
1999.05.27
申请号
WO1998GB03338
申请日期
1998.11.09
申请人
ZENECA LIMITED;DRAKE, CAROLINE, RACHEL;OSBORN, RUPERT, WILLIAM;EVANS, IAN, JEFFREY;RAY, JOHN, ANTHONY
发明人
DRAKE, CAROLINE, RACHEL;OSBORN, RUPERT, WILLIAM;EVANS, IAN, JEFFREY;RAY, JOHN, ANTHONY