PYRIDYLPYRROLE DERIVATIVES

摘要

Object: to provide compounds having an inhibitory effect on the production of inflammatory cytokines. Constitution: compounds having general formula (I), pharmacologically acceptable salts thereof or derivatives of the same, wherein A: single bond, oxygen, sulfur, CO, SO, SO2, C(R<9>)(R<10>) [R<9>, R<10>: H, OH, halogeno, alkyl], N(R<11>), C=NOR<11> [R<11>: H, alkyl]; D: single bond, C(R<12>)(R<13>) [R<12>, R<13>: H, OH, halogeno, alkyl]; R<1>: optionally substituted pyridyl; R<2>: optionally substituted phenyl; R<3>: halogeno, alkyl, haloalkyl, alkoxy, haloalkoxy; R<4>, R<5>, R<6>, R<7>, R<8>: H, alkyl; k: 0-3; and m: 1, 2.