发明名称 |
USE OF ACTIN-BINDING COMPOUNDS FOR THE MANUFACTURE OF A MEDICAMENT FOR REDUCING THE VISCOSITY OF PATHOLOGICAL MUCOID AIRWAY CONTENTS IN THE RESPIRATORY TRACT |
摘要 |
<p>The invention is generally directed to methods of promoting normal respiratory tract airflow in subjects with restricted airflow and ciliary clearance caused by the presence of pathological airway contents, and particularly mucoid contents. Actin-binding proteins are administered into the respiratory tract of a subject with a pathological respiratory condition involving the presence of such contents. The actin-binding protein binds to actin polymers in the contents and decreases the viscosity. The actin binding proteins also prevent actin from binding to exogenous or endogenous DNase, thus increasing the degradation of DNA polymers in the contents.</p> |
申请公布号 |
EP0692970(B1) |
申请公布日期 |
1999.08.04 |
申请号 |
EP19940914023 |
申请日期 |
1994.04.04 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
STOSSEL, THOMAS, P.;LIND, STUART, E.;JANMEY, PAUL, A. |
分类号 |
A61K38/00;A61K38/17;A61K38/46;A61P11/00;A61P11/12;C07K14/47;G01N33/68;(IPC1-7):A61K38/17 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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