发明名称 |
Method and kit for detecting heparin induced thrombocytopenia |
摘要 |
A method of detecting heparin-induced antibodies to complete a diagnosis of heparin-induced thrombocytopenia (HITP) is disclosed. This method comprises the first step of attaching a glycosaminoglycan to a solid support, wherein the glycosaminoglycan is attached to the solid support only at the reducing end of the molecule (unidirectionally). Platelet factor 4 is then bound to the glycosaminoglycan forming a complex having an epitope recognizable by antibodies generated in an HITP immune response. Human blood plasma or serum from a patient suspected of having HITP is exposed to the complex and the complex is analyzed to determine if HITP-related antibodies are present. A device and kit used in performing the diagnostic assay are also disclosed.
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申请公布号 |
US5972717(A) |
申请公布日期 |
1999.10.26 |
申请号 |
US19970974331 |
申请日期 |
1997.11.19 |
申请人 |
THE BLOOD CENTER RESEARCH FOUNDATION, INC. |
发明人 |
ASTER, RICHARD H.;VISENTIN, GIAN |
分类号 |
G01N33/86;(IPC1-7):C12Q1/56;C12Q1/28;G01N33/53;G01N33/563 |
主分类号 |
G01N33/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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