| 发明名称 |
Substituted azetidin-2-ones for treatment of atherosclerosis |
| 摘要 |
PCT No. PCT/EP95/05130 Sec. 371 Date Nov. 21, 1997 Sec. 102(e) Date Nov. 21, 1997 PCT Filed Dec. 20, 1995 PCT Pub. No. WO96/19451 PCT Pub. Date Jun. 27, 1996Compounds of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen, halogen or C(1-8)alkyl; R3 is aryl or aryl C(1-4)alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA2 and thereof of use in treating atherosclerosis.
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| 申请公布号 |
US5990102(A) |
申请公布日期 |
1999.11.23 |
| 申请号 |
US19970860162 |
申请日期 |
1997.11.21 |
| 申请人 |
SMITHKLINE BEECHAM P.L.C. |
发明人 |
HICKEY, DEIRDRE MARY BERNADETTE;DHANAK, DASHYANT;LEACH, COLIN ANDREW;IFE, ROBERT JOHN;TEW, DAVID GRAHAM |
| 分类号 |
A61K31/395;A61K31/397;A61P3/06;A61P3/08;A61P3/10;A61P9/00;A61P9/10;A61P9/12;A61P25/00;A61P29/00;A61P43/00;C07D205/09;(IPC1-7):A61K31/395 |
主分类号 |
A61K31/395 |
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