A NOVEL HUMAN THROMBOPOIETIN MUTEIN

摘要

The present invention relates to novel human thrombopoietin (hTPO) derivatives, and to process of preparation thereof. Particularly, sugar chai ns are introduced into native hTPO by substituting amino acids such as asparagi ne for amino acids at specific positions in native hTPO, preparing novel hTPO derivatives with high activities enhancing the platelet production in vivo. Therefore, the novel hTPO derivatives of this invention may be useful for th e treatment of thrombocytopenia associated with anticancer therapy or the transplantation of bone marrow.