| 发明名称 |
Inhibitors of prenyl-protein transferase |
| 摘要 |
The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras. |
| 申请公布号 |
AU4845099(A) |
申请公布日期 |
2000.01.24 |
| 申请号 |
AU19990048450 |
申请日期 |
1999.06.29 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
CHRISTOPHER J. DINSMORE;JEFFREY M BERGMAN;SAMUEL L. GRAHAM;DIEM L. NGUYEN;GERALD E. STOKKER;THERESA M. WILLIAMS;C. BLAIR ZARTMAN |
| 分类号 |
A61K31/337;A61K31/4995;A61P9/00;A61P9/10;A61P13/12;A61P27/02;A61P31/10;A61P31/12;A61P31/14;A61P35/00;A61P43/00;C07D498/18;C07D498/22 |
主分类号 |
A61K31/337 |
| 代理机构 |
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代理人 |
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| 主权项 |
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