METAL-CONTAINING COMPOUNDS AND THEIR USE FOR INHIBITING THE IMMUNE RESPONSE

摘要

Use of compounds as immunosuppressive agents to prevent or significantly reduce graft rejection in organ and bone marrow transplantation is described. The compounds described herein can also be used as immunosuppressant drugs for T-lymphocyte mediated autoimmune diseases, such as diabetes, and may be useful in alleviating psoriasis and contact dermatitis. The compounds can also be used therapeutically in the treatment of hyperproliferative vascular disease and to reduce/suppress the immune response in a mammal undergoing gene therapy.