CONDENSED TROPANIC DERIVATIVES AS NEUROMEDIATOR REVERSE CAPTURE INHIBITORS

摘要

chemical industry. SUBSTANCE: described are condensed tropanic derivatives of formula I: wherein X and Y together form =O,=,NOR3,=CR3R4, either one of X and Y is hydrogen an the other is -OR5,SR5,-NR5R6; Z is hydrogen; R3 and R4 are independently hydrogen, lower alkyl, lower alkenyl, phenyl (lower alkyl) or -(CH2)q-COOR2; R2,R5,R6 are independently hydrogen, lower alkyl, lower alkenyl, - CO-(lower alkyl), phenyl (lower alkyl) or -SO2-(lower alkyl); R1 is lower alkyl or phenyl optionally substituted by halogen, CF3, CN, lower alkyl or nitro; n is 1 or 2; q is 0. Said compounds are useful as medicinals having properties of inhibiting reverse capture of neutromediatory monoamines in central nervous systems. EFFECT: improved properties of the title compounds. 8 cl, 30 ex, 3 tbl