SYSTEMS AND METHODS FOR CROSS-LINKING TREATMENTS OF AN EYE

摘要

A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

主权项

1. A system for corneal treatment, comprising:
a light source configured to activate cross-linking in at least one selected region of a cornea treated with a cross-linking agent, the light source being configured to deliver photoactivating light to the at least one selected region of the cornea according to a set of parameters; and a controller configured to receive input relating to the cross-linking agent and the set of parameters for the delivery of the photoactivating light, the controller including computer-readable storage media storing:
(A) a first set of program instructions for determining, from the input, cross-linking resulting from reactions involving reactive oxygen species (ROS) including at least peroxides, superoxides, and hydroxyl radicals, and(B) a second set of program instructions for determining, from the input, cross-linking from reactions not involving oxygen,the controller being configured to execute the first and second sets of program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea,
wherein, in response to the calculated amount of cross-linking output by the controller, the light source is configured to adjust at least one value in the set of parameters for the delivery of the photoactivating light.