| 发明名称 |
Coformulation methods and their products |
| 摘要 |
A coformulation of an active (preferably pharmaceutically active, for instance a COX-2 enzyme inhibitor) substance and an oligomeric or polymeric excipient, containing at least 10% of the active, between 80 and 100% of which is amorphous. The amorphous phase is stable, with respect to the crystalline phase(s), for at least three months after its preparation when stored at between 0 and 10{C. The invention also provides processes, preferably involving SEDS<SP>TM</SP> particle formation, for preparing such a coformulation. |
| 申请公布号 |
AU6855000(A) |
申请公布日期 |
2001.03.26 |
| 申请号 |
AU20000068550 |
申请日期 |
2000.08.31 |
| 申请人 |
BRADFORD PARTICLE DESIGN PLC;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
PETER YORK;SIMON ANTHONY WILKINS;RICHARD ANTHONY STOREY;STEPHEN ERNEST WALKER;RONALD SCOTT HARLAND |
| 分类号 |
A61K9/14;A61K9/16;A61K31/167;A61K31/192;A61K31/341;A61K31/375;A61K31/40;A61K31/405;A61K31/444;A61K31/522;A61K31/55;A61K45/00;A61K47/30;A61K47/32;A61K47/34;A61K47/38;A61P15/06;A61P19/02;A61P25/04;A61P29/00;A61P43/00 |
主分类号 |
A61K9/14 |
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