发明名称 |
Sustained-release leuprorelin preparation |
摘要 |
<p>A sustained-release preparation which comprises a physiologically active peptide of general formula <CHEM> wherein X represents an acyl group; R1, R2 and R4 each represents an aromatic cyclic group; R3 represents a D-amino acid residue or a group of the formula <CHEM> wherein R3' is a heterocyclic group; R5 represents a group of the formula -(CH2)n-R5' wherein n is 2 or 3, and R5' is an amino group which may optionally be substituted, an aromatic cyclic group or an O-glycosyl group; R6 represents a group of the formula -(CH2)n-R6' wherein n is 2 or 3, and R6' is an amino group which may optionally be substituted; R7 represents a D-amino acid residue or an azaglycyl residue; and Q represents hydrogen or a lower alkyl group, or a salt thereof and a biodegradable polymer having a terminal carboxyl group. The sustained-release preparation shows a constant release of the peptide over a long time without an initial burst.</p> |
申请公布号 |
EP1088555(A1) |
申请公布日期 |
2001.04.04 |
申请号 |
EP20000203850 |
申请日期 |
1993.12.03 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
KAMEI, SHIGERU;IGARI, YASUTAKA;OGAWA, YASUAKI |
分类号 |
A61K9/52;A61K;A61K9/16;A61K9/22;A61K9/50;A61K38/04;A61K38/09;A61K38/12;A61K47/34;A61K47/42;C07K7/23;(IPC1-7):A61K38/09 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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