| 摘要 |
PURPOSE: Provided are cyano indolesn having an inhibitory activity of serotonin reuptake , their enantiomers, diastereoisomers, and their salts with acids and bases, their preparation, and pharmaceutical compositions containing them. CONSTITUTION: Cyano indoles are represented by formula(I): R1 and R2 are H or 1-6C alkyl; T1 and T2 are 1-6C alkylene; G is a heterocyclic group of formula(alpha) or (beta); W1, W2 and W3 are N, CR5, NR4 or CO; W4 is N, CR3, NR4, or CO; W5 is C or N; X1 is a bond, N, CR3 or NR4; X2 to X4 are CR3, NR4, CO, SR4, SO2, O, S, or N; R3 is H, halogen, 1-6C alkyl, OH, 1-6C perhaloalkyl, NO2, NH2, mono- or di alkylamino, or benzylamino; R4 is H, 1-6C alkyl, or optionally substituted aryl or aralkyl; and R5 is a group R3 or two adjacent groups R5 form, together with the C atoms to which they are attached, a saturated or unsaturated mono- or bicyclic group that may contain 1-5 O, N, or S hetero atoms and which may be substituted by R3 or oxo.
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