Curcuminoid complexes with enhanced stability, solubility and/or bioavailability

摘要

Methods and materials relating to a medicament preparation comprising a curcuminoid component and a euradit component provided as a curcuminoid-eudragit complex, which enhance the bioavailability of the curcumin component and are useful for the treatment of various diseases including cancer, neurodegeneration, inflammation, and immunodeficiency. In some aspects, the curcuminoid component comprises curcumin to prepare a curcumin-eudragit complex and a medicament comprising curcumin-eudragit complexes.

主权项

1. A curcuminoid composition comprising:
a curcuminoid-polymer complex comprising at least one curcuminoid component selected from the group consisting of curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydroxycurcumin, Bis-0-Demethyl curcumin (BDMC), or combinations thereof; at least one polymer or co-polymer component having a backbone comprising polymethacrylate or methyl methacrylate; and surfactant component, wherein the curcuminoid component and the polymer or co-polymer component are in the form of the curcuminoid-polymer complex having a plurality of particles with an average particle size between about 10.0 nm and about 5000.0 nm; and wherein the curcuminoid-polymer complex is formed by a process comprising:
dissolving the curmuminoid component and the polymer or co-polymer component in an organic solvent to form a curmuminoid-polymer solution;adding the curmuminoid-polymer solution to an aqueous solution having the surfactant to to precipitated the curcuminoid-polymer complex and form a dispersion; andremoving the organic solvent from the dispersion to collect the curcumoid-polymer complex.