| 摘要 |
<p>The present invention relates to a nucleic acid molecule encoding a (poly)peptide regulating, causing or contributing to obesity in an animal or a human wherein said nucleic acid molecule (a) hybridizes under herein defined conditions to the complementary strand of a nucleic acid molecule encoding the amino acid sequence disclosed ehrein; (b) hybridizes under herein defined conditions to the complementary strand of a nucleic acid molecule comprising the nucleic acid sequence disclosed herein; (c) is degenerate with respect to the nucleic acid molecule of (a); (d) encodes a (poly) peptide which is at least 35 % and up to 99,8 % identical to a herein disclosed amino acid sequence representing a (poly)peptide regulating, causing or contributing to obesity; (e) encodes a (poly)peptide which is at least 35 % identical to amino acid sequences as disclosed herein; (f) comprises a portion that is amplified in a polymerase chain reaction carried out on a Drosophila, mouse or human cDNA library or on genomic Drosophila, mouse or human DNA with set(s) of primers herein defined under conditions as disclosed herein, or (g) encodes a (poly)peptide which comprises at least one WD40 motif and at least one TPR-motif.</p> |
