METHODS FOR ISOLATING ONE STRAND OF A DOUBLE-STRANDED NUCLEIC ACID
摘要
The present invention provides methods and kits for isolating one strand of a double-stranded target nucleic acid. The method capitalizes on the differences in the kinetics and thermodynamic stabilities between conventional DNA/DNA, DNA/RNA and RNA/RNA duplexes and heteroduplexes in which one strand of the heteroduplexe is a nucleobase polymer having a net positively charged or net neutral backbone, such as a PNA.
申请公布号
WO0210182(A2)
申请公布日期
2002.02.07
申请号
WO2001US22782
申请日期
2001.07.18
申请人
PE CORPORATION (NY);CHIESA, CLAUDIA;SCHROTH, GARY, P.;EGHOLM, MICHAEL