Novel araquidonic acid derivatives with affinity toward the anandamide transporter

摘要

The invention relates to compounds derived from araquidonic acid of general formula (I), their stereoisomers and mixtures and their pharmaceutically acceptable salts and solvates. The invention also relates to a method for preparing the above-mentioned compounds, pharmacological characterization and therapeutic applications, wherein X represents CO, CS or CH2; Y represents CH2, O, S, NH or NR (R represents alkyl, alkylaryl or aryl); Z represents H or an alkyl, alkylaryl or aryl group; Heterocycle represents an aromatic monocyclic subunit or an aliphatic monocyclic subunit consisting of one or two heteroatoms and methylenic units or the benzofused derivatives of both subunits.