发明名称 |
Highly efficient delivery of a large therapeutic mass aerosol |
摘要 |
A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles. Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included. |
申请公布号 |
US2002035993(A1) |
申请公布日期 |
2002.03.28 |
申请号 |
US20010878146 |
申请日期 |
2001.06.08 |
申请人 |
ADVANCED INHALATION RESEARCH, INC. |
发明人 |
EDWARDS DAVID A.;BATYCKY RICHARD P.;JOHNSTON LLOYD |
分类号 |
A61K9/12;A61K9/00;A61K9/14;A61K9/16;A61K9/72;A61K31/137;A61K31/198;A61K31/46;A61K31/56;A61K38/27;A61K38/28;A61K39/395;A61L9/04;B05D7/14;(IPC1-7):B05D7/14;A61M15/00;A61M16/00;B65D83/06 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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